Sandesh C.S. Nagamani, M.B.B.S, M.D., FACMG
Picture
Positions
- Professor
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Molecular and Human Genetics
草榴社区入口
Houston, TX US
- Vice Chair, Clinical Research Affairs
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Molecular and Human Genetics
草榴社区入口
- Professor
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Department of Medicine
草榴社区入口
- Director
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BCM Intellectual and Developmental Disabilities Research Center
草榴社区入口
- Director
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BCM Intellectual and Developmental Disabilities Research Center
Clinical Translational Core
Addresses
- Adult Genetics Clinic (Clinic)
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草榴社区入口 Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
Phone: (713) 798-7820
Adult Genetics Clinic
Education
- Residency at Baylor College Of Medicine
- 10/2009 - Houston, Texas United States
- Internal Medicine
- Postdoctoral Training at Baylor College Of Medicine
- 06/2009 - Houston, Texas United States
- Clinical Genetics
- Residency at Baylor College Of Medicine
- 06/2008 - Houston, Texas United States
- Clinical Genetics
- Residency at Fairview Hospital, A Cleveland Clinic Hospital
- 06/2006 - Cleveland, Ohio United States
- Residency at Gandhi Medical College
- 01/2003 - Bhopal, India
- Internal Medicine
- MBBS from University of Mysore
- 01/1999 - Mysore, India
- Medical School
Certifications
- American Board of Medical Genetics and Genomics
- American Board of Internal Medicine
Honors & Awards
- Rising Star Award
- 草榴社区入口 (05/2015)
- Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation
- 11/2016
- Norton Rose Fulbright Faculty Excellence Award for Creation of Enduring Materials
- 05/2021
- Member, Academy of Distinguished Educators at BCM
- Clark Faculty Service Award
- BCM (05/2023)
- Adult Genetics Excellence in Education Award
- 2012, 2013, 2015, 2016, 2022
- Department of Molecular and Human Genetics, 草榴社区入口
- Doris Duke Foundation Paragon Award for Research Excellence
- 10/2023
Professional Statement
I am an internist and a clinical geneticist who is focused on improving clinical care in individuals with genetic disorders. The focus of my research program is clinical investigation including conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in individuals with inborn errors of metabolism and skeletal dysplasias.Inborn Errors of Metabolism: I served as Multiple Principal Investigator (MPI) for the NIH Rare Diseases Clinical Research Network鈥檚 Urea Cycle Disorders Consortium (UCDC) and contact PI for the Pilot/Feasibility core and the career enhancement core of the consortium. The UCDC has implemented 19 studies that have collectively enrolled a more than1600 participants, trained nearly 30 early career investigators, and facilitated the development of novel biomarkers, clinical endpoints, and therapies for urea cycle disorders.
Skeletal dysplasia: As a lead investigator of the NIH Rare Diseases Clinical Research Network鈥檚 Brittle Bone Disorders Consortium, I am involved in conducting natural history studies and interventional clinical trials in individuals with osteogenesis imperfecta, the most common osteodysplasia in humans. I have developed clinical endpoints and biomarkers to assess disease burden from the perspective of clinical trial readiness and had lead roles in clinical trials evaluating novel therapies for OI including the first disease-specific therapy with anti-transforming growth factor beta antibody.
Clinical Interests: As an internist and clinical geneticist, I provide care to adults with a wide variety of heritable conditions including osteogenesis imperfecta, genetic skeletal disorders, intellectual and developmental disabilities, Mendelian forms of cancer, and heritable connective tissue disorders.
Intellectual and Developmental Disabilities Research Center: I serve as MPI and Director for the NICHD-funded Intellectual and Developmental Disabilities Research Center at BCM. Our center supports translational research activities of more than 80 investigators engaged in advancing research and clinical care for individuals with intellectual and developmental disabilities.
Educational Activities: On the educational front, I have been heavily involved in patient-outreach activities and education of early career investigators. I have assisted in developing resources for education of families and physicians across our country about specific rare disorders. I have worked with the TeleECHO program to implement and deliver virtual training materials to patients and providers. The latter project has used guided-practice model to reduce health disparities in under-served and remote areas through innovative tele-mentoring.
Websites
Selected Publications
- "." ;
- Nagamani SCS, Ali S, Izem R, Schady D, Masand P, Shneider BL, Leung DH, Burrage LC "." Mol Genet Metab. 2021 Jun;133:148-156. Pubmed PMID:
- Song IW*, Nagamani SC*, Nguyen D, Grafe I, Sutton VR, Gannon FH, Munivez E, Jiang MM, Tran A, Wallace M, Esposito P, Musaad S, Strudthoff E, McGuire S, Thornton M, Shenava V, Rosenfeld S, Shypailo R, Orwoll E, Lee B "." J Clin Invest. 2022;132:e152571. Pubmed PMID:
- Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, Harris G, Sutton VR, Lee B, Members of the BBDC, Nagamani SCS. "." Genet Med. 2020;22:581-589. Pubmed PMID:
- Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, (...), Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A "." Cell. 2018;174:1559-1570.e22. Pubmed PMID:
- Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH "." Am J Hum Genet.. 2018;103:276-287. Pubmed PMID:
- Nagamani SCS, Agarwal U, Tam A, Azamian M, McMeans A, Didelija IC, Mohammad MA, Marini JC "." Genet Med.. 2018;20:708-716. Pubmed PMID:
- Jain M, Tam A, Shapiro JR, Steiner RD, Smith PA, (...), Members of the Brittle Bone Disorders Consortium*, Nagamani SCS "." Genet Med.. 2018;21:275-283. Pubmed PMID:
- Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC "." J Nutr.. 2017;147:549-555.. Pubmed PMID:
- Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Igor Ulitsky, Nagamani SC, Ruppin E and Erez A "." Nature. 2015 Nov;527(7578):379-83. Pubmed PMID:
- Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B "." Nat Med. 2011 Nov 13;17(12):1619-26. Pubmed PMID:
- Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B "." Am J Hum Genet. 2012 May 4;90(5):836-46. Pubmed PMID:
- Orwoll ES, Shapiro J, Veith S, Wang Y, Lapidus J, Vanek C, Reeder JL, Keaveny TM, Lee DC, Mullins MA, Nagamani SC, Lee B "." J Clin Invest. 2014 Feb 3;124(2):491-8. Pubmed PMID:
- Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, et al "." Mol Genet Metab. 2012 Nov;107(3):315-21. Pubmed PMID:
- Liu P, Erez A, Nagamani SC, Dhar SU, Ko艂odziejska KE, Dharmadhikari AV, et al "." Cell. 2011 Sep 16;146(6):889-903. Pubmed PMID:
- Bellur S, Jain M, Cuthbertson D, Krakow D, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Krischer J, Mullins MA, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B, 鈥淢embers of the BBD Consortium鈥, and SC Nagamani "." Genetics in Medicine. 2016 Oct;18:570-6. Pubmed PMID:
Memberships
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
- Member
- American College of Medical Genetics
- Elected Fellow
- American Society for Bone and Mineral Research
- Member
- American Society of Human Genetics
- Member
Funding
- Co-Principal Investigator for the NIH RDCRN's Urea Cycle Disorders Consortium - #U54HD061221
- ( 08/01/2014 ) Grant funding from NCATS, NICHD, NIDDK for the RDCRN
- Principal Investigator, Clinical Translational Core, IDDRC - #P50HD103555
- ( 08/01/2019 ) Grant funding from NICHD
- Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency - #R01AR071741
- ( 04/01/2017 ) Grant funding from NIAMS
- U54 Career Enhancement Core, Brittle Bone Disorders Consortium - #AR068069
- ( 08/01/2019 ) Grant funding from NCATS, NIAMS, NIDCR, NIHMS, NICHD for the RDCRN
- Intellectual and Developmental Disabilities Research Center - #P50 HD103555 Grant funding from NICHD
- PI
- Career Enhancement Core - #U54 HD061221 Grant funding from NCATS, NICHD, NIDDK for the RDCRN
- Pilot Feasibility Core - #U54 HD061221 Grant funding from NCATS, NICHD, NIDDK
Languages
Hindi, Kannada
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