²ÝÁñÉçÇøÈë¿Ú

Email

daniel.calame@bcm.edu

Positions

Instructor

Pediatrics
Pediatric Neurology and Developmental Neurosciences
²ÝÁñÉçÇøÈë¿Ú
Houston, TX US

Honors & Awards

MDA Development Award

Muscular Dystrophy Association

Chao Physician Scientist Award

²ÝÁñÉçÇøÈë¿Ú

CNCDP-K12

NINDS, Kennedy-Krieger Institute

Burroughs Wellcome Fund Career Award for Medical Scientist Finalist

Professional Interests

• Clinical neurogenetics
• Neurodevelopmental disorders
• Hereditary spastic paraplegia
• Pathogenesis of developmental movement disorders
• Cerebral palsy
• Human genetics and genomics

Professional Statement

Despite advances in genome-wide technologies including exome sequencing, short-read whole genome sequencing, and array comparative genomic hybridization, diagnostic genetic testing fails to deliver a definitive diagnosis to most patients with rare neurogenetic diseases including muscular dystrophies, neuropathies, epilepsy, cerebral palsy, and neurodevelopmental disorders. In both my clinical practice and my research in Jim Lupski's lab as part of the ²ÝÁñÉçÇøÈë¿Ú Genomics Research Elucidates the Genetics of Rare disease (BCM-GREGoR) program I am fully committed to ‘solving the unsolved’ – to find genetic answers and end the diagnostic odyssey for patients and families with rare diseases. In addition, I am interested in better characterization of the phenotypic spectrum and natural history of rare diseases to improve anticipatory guidance and prognostication and develop clinical trials readiness.

Selected Publications

• Calame DG, Bakhtiari S, et al. "." Genet Med. 2021;23(12)(12):2455-2460. Pubmed PMID:
• Calame DG, Herman I, et al "." Ann Neurol. 2022;92(2):304-321. Pubmed PMID:
• Daniel G Calame, Tianyu Guo , Chen Wang, et al. "." Am J Hum Genet. 2023 Aug 3;110(8):1394-1413. Pubmed PMID:
• Brown et al. "." Nature. 2022;605(7909):349-356. Pubmed PMID:

Memberships

Child Neurology Society

American Academy of Neurology

American Academy of Pediatrics

Alpha Omega Alpha