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Direct cardiac reprogramming approach uses specific genes to directly convert the fibroblasts into cardiac myocytes. At the HEART Center, we are developing innovative gene therapies based on direct cardiac reprogramming, a cutting-edge approach that transforms existing cells into heart cells. Our preclinical studies have shown promising results, including improved heart function and tissue regeneration following gene delivery. To ensure safety and efficiency, we are exploring multiple delivery methods-such as viral vectors and non-viral techniques-to introduce therapeutic genes into the heart. In addition, our research focuses on identifying:
- The most effective gene combinations
- The optimal timing for delivery
- The molecular mechanisms behind direct reprogramming
